University of California, Riverside

Division of Biomedical Sciences



Biomedical Sciences Faculty


Marcus Kaul

Associate Professor of Biomedical Sciences

Marcus Kaul

University of California, Riverside
Riverside, CA 92521

Tel: (951) 827-4349
Fax: (951) 827-4294
E-mail: marcus.kaul@medsch.ucr.edu
Office: 311 School of Medicine Research Building

Education and Training

  • Fellowship, Harvard Medical School, Boston, Massachusetts
  • Ph.D., Johannes Gutenberg-University, Mainz, Germany
  • Residency, Pharmacy, Merian-Apotheke, Frankfurt/Main, Germany
  • B.Sc., Pharmacy, Johann-Wolfgang von Goethe-University, Frankfurt/Main, Germany

Biography

Marcus Kaul, Ph.D. is an associate professor of the UC Riverside School of Medicine Division of Biomedical Sciences.

Prior to joining UCR, Kaul was an associate professor in the department of psychiatry of UC San Diego and the Infectious and Inflammatory Disease Center for the Sanford Burnham Prebys Medical Discovery Institute in La Jolla, Calif.

Kaul completed his education and residency in pharmacology before coming to the United States in 1997 to begin his postdoctoral fellowship in 1997. Since then, he has been working in Southern California as a faculty member and research associate in institutions including the Burnham Institute, UC San Diego, and CSU San Marcos.

He is currently a member in several professional associations, including the Society for Neuroimmune Pharmacology and the American Association of Immunologists.

Research Interests

Kaul is studying the role of lipocalin-2 and cysteinyl leukotrienes in HIV-associated neuronal injury. This research is meant to characterize the apparent role of a small acute phase protein and a lipid mediator in the pathological mechanisms that contribute to HIV-associated neurocognitive disorders and dementia using novel in vivo and in vitro models. This ties into Kaul’s interests in cellular and molecular mechanisms of neurodegenerative diseases linked with host-pathogen interactions.

Kaul is also researching neuroprotection by IFN-beta in AIDS to characterize the neuroprotective effect of IFNβ against toxicity of HIV/gp120 using in vivo and in vitro models.

Kaul’s other major research interests include:

  • The influence of drug abuse on neural plasticity and host-pathogen interactions, in particular HIV-1 infection and associated neuroimmunological pathology and behavioral performance. A recent focus in this context is the potential role of microRNAs and long-non-coding RNAs and the application of next generation sequencing (currently SOLiDTM System).
  • The biology of stem and progenitor cells in particular differentiation and function of neural and immune cell types with particular consideration of chronic inflammatory and degenerative processes, substance abuse and neurocognitive impairment.

Selected Publications

  • Sanchez, A.B., Varano, G.P., de Rozieres, C.M., Maung, R., Catalan, I.C., Dowling, C.C., Sejbuk, N.E., Hoefer, M.M., Kaul, M. (2016). Antiretrovirals, methamphetamine and HIV-1 envelope protein gp120 compromise neuronal energy homeostasis in association with varying degrees of synaptic and neuritic damage. Antimicrob Agents Chemother. 60(1): 168-179. Online available 2015 Oct 19; doi: 10.1128/AAC.01632-15.
  • Hoefer, M.M., Sanchez, A.B, Maung R., de Rozieres, C.M., Catalan, I.C., Dowling, C.C. Thaney, V.E., Piña-Crespo, J., Zhang, D, Roberts, A.J., Kaul, M. (2015). Combination of Methamphetamine and HIV/gp120 causes distinct long-term alterations of behavior, gene expression, and injury in the central nervous system. Exp. Neurol. 263: 221-234, doi: 10.1016/j.expneurol.2014.09.010. Epub 2014 Sep 20.
  • Maung, R., Sejbuk, N.E., Russo, R., Hoefer, M.M., Sanchez, A.B., Medders, K.E., Desai, M.K., Catalan, I.C., Dowling, C.C., DeRozieres, C.M., Garden, G.A., Roberts, A.J., Williams, R., Kaul, M. (2014). CCR5 knockout prevents neuronal injury and behavioral impairment induced in a transgenic mouse model by a CXCR4-using HIV-1 glycoprotein 120. J. Immunol. 193: 1895-1910. Published online July 16, 2014, doi: 10.4049/jimmunol.1302915
  • Teodorof, C., Divakar, S., Soontornniyomkij, B., Achim, C.L.; Kaul, M., Singh, K.K. (2014) Intracellular mannose binding lectin mediates subcellular trafficking of HIV-1 gp120 in neurons. Neurobiol. Dis. 69C: 54-64. doi: 10.1016/j.nbd.2014.05.002.
  • Kang, Y., Tiziani, S., Park, G., Kaul, M., Paternostro, G. (2014) Cellular protection using Flt3 and PI3Kα inhibitors demonstrates multiple mechanisms of oxidative glutamate toxicity. Nat. Commun. 5: 3672. doi: 10.1038/ncomms4672
  • Wang, R., Kaul, M., Zhang, D. (2012). Interferon-stimulated gene 15 (Isg15) as a general marker for acute and chronic neuronal injuries. Acta Physiologica Sinica (Sheng Li Xue Bao). 64(5): 577-583.
  • Maung, R., Medders, K.E., Sejbuk, N.E., Desai, M.K., Russo, R., Kaul, M. (2012). Genetic knockouts suggest a critical role for HIV co-receptors in models of HIV gp120-induced brain injury. J. Neuroimmune Pharmacol. 7: 306-318. Published online: 2 Dec. 2011 DOI: 10.1007/s11481-011-9328-x.
  • Medders, K.E., Kaul, M. (2011). Mitogen-activated protein kinase p38 in HIV-infection and associated brain injury. J. Neuroimmune Pharmacol. 6: 202-215. Published online: 1 Feb. 2011 DOI 10.1007/s11481-011-9260-0.
  • Letendre, S.L., Zheng, J.C., Kaul, M., Yiannoutsos, C.T., Ellis, R.J., Taylor, M.J., Marquie-Beck, J., Navia, B.; for the HIV Neuroimaging Consortium. (2011). Chemokines in cerebrospinal fluid correlate with cerebral metabolite patterns in HIV-infected individuals. J. Neurovirol. 17: 63-69. Published online: 19 Jan. 2011 DOI 10.1007/s13365-010-0013-2

More Information 

General Campus Information

University of California, Riverside
900 University Ave.
Riverside, CA 92521
Tel: (951) 827-1012

Department Information

Division of Biomedical Sciences
UC Riverside School of Medicine
2608 School of Medicine Education Building

Tel: (951) 827-5470

Related Links

Footer